Entry 1 sense Webster, 1913 Agonizingly /ăg'-ən-īzˌ-ĭng-lēˌ/ · Ag·o·ni·zing·ly · IPA /ˈæɡ.ə.naɪ.zɪŋ.li/ 01 adv. With extreme anguish or desperate struggles. 1. With extreme anguish or desperate struggles.