Entry 1 sense Webster, 1913 Axolotl · Ax·o·lotl · IPA /ˈæk.səˌlɑ.təl/ 01 n. An amphibian of the salamander tribe found in the elevated lakes of Mexico; the siredon. 1. An amphibian of the salamander tribe found in the elevated lakes of Mexico; the siredon.(Zool.)