Entry 1 sense Webster, 1913 Cayenne /kīˌ-ĕn'/ · Cay·enne · IPA /kaɪˈɛn/ 01 n. Cayenne pepper. 1. Cayenne pepper. Phrases & compounds Cayenne pepper — A species of Capsicum (Capsicum frutescens) with small and intensely pungent fruit.