Entry 1 sense Webster, 1913 Chalice /chăl'-ĭs/ · Chal·ice · IPA /ˈt͡ʃæl.ɪs/ 01 n. A cup or bowl; especially, the cup used in the sacrament of the Lord's Supper. 1. A cup or bowl; especially, the cup used in the sacrament of the Lord's Supper.