Entry 2 senses · 2 variants Webster, 1913 Depurate · Dep·u·rate · IPA /ˈdɛpjʊəɹeɪt/ a. v. t. 01 a. Depurated; cleansed; freed from impurities. 1. Depurated; cleansed; freed from impurities. 02 v. t. To free from impurities, heterogeneous matter, or feculence; to purify; to cleanse. imp. & p. p. Depurated; p. pr. & vb. n. Depurating 1. To free from impurities, heterogeneous matter, or feculence; to purify; to cleanse. “To depurate the mass of blood.” — Boyle.