Entry 1 sense Webster, 1913 Desecration /dĕs-ək-rāsh'-ən/ · Des·e·cra·tion · IPA /dɛ.sɪˈkɹeɪ.ʃən/ 01 n. The act of desecrating; profanation; condition of anything desecrated. 1. The act of desecrating; profanation; condition of anything desecrated.