Entry 3 senses · 2 variants Webster, 1913 Ephesian · E·phe·sian · IPA /ɪˈfiːʒən/ a. n. 01 a. Of or pertaining to Ephesus, an ancient city of Ionia, in Asia Minor. 1. Of or pertaining to Ephesus, an ancient city of Ionia, in Asia Minor. 02 n. A native of Ephesus. 1. A native of Ephesus. 2. A jolly companion; a roisterer.[Obs.]