Entry 2 senses · 2 variants Webster, 1913 Epispastic · Ep·i·spas·tic · IPA a. n. 01 a. Attracting the humors to the skin; exciting action in the skin; blistering. 1. Attracting the humors to the skin; exciting action in the skin; blistering.(Med.) 02 n. An external application to the skin, which produces a puriform or serous discharge by exciting inflammation; a vesicatory. 1. An external application to the skin, which produces a puriform or serous discharge by exciting inflammation; a vesicatory.(Med.)