Entry 2 senses · 2 variants Webster, 1913 Flyspeck /(flī"spĕk)/ · Fly·speck · IPA n. v. t. 01 n. A speck or stain made by the excrement of a fly; hence, any insignificant dot. 1. A speck or stain made by the excrement of a fly; hence, any insignificant dot. 02 v. t. To soil with flyspecks. 1. To soil with flyspecks.