Entry 2 senses Webster, 1913 Homicide /hämʹə-sīdˈ/ · Hom·i·cide · IPA /ˈhɑm.əˌsaɪ̯d/ 01 n. The killing of one human being by another. 1. The killing of one human being by another. 2. One who kills another; a manslayer.