Entry 1 sense Webster, 1913 Hydrogenation /hīdˌ-räjˌ-ən-āsh'-ən/ · Hy·dro·gen·a·tion · IPA /hˌaɪdrˌɑdʒənˈeɪʃən/ 01 n. The act of combining with hydrogen, or the state of being so combined. 1. The act of combining with hydrogen, or the state of being so combined.(Chem.)