Entry 1 sense Webster, 1913 Irk /(ẽrk)/ · IPA /ɝk/ 01 v. t. To weary; to give pain; to annoy. 1. To weary; to give pain; to annoy. “To see this sight, it irks my very soul.” — Shak. “It irketh him to be here.” — M. Arnold.