Entry 3 senses · 2 variants Webster, 1913 Lenitive /(-tĭv)/ · Len·i·tive · IPA a. n. 01 a. Having the quality of softening or mitigating, as pain or acrimony; assuasive; emollient. 1. Having the quality of softening or mitigating, as pain or acrimony; assuasive; emollient. 02 n. A medicine or application that has the quality of easing pain or protecting from the action of irritants. 1. A medicine or application that has the quality of easing pain or protecting from the action of irritants.(Med.) 2. That which softens or mitigates; that which tends to allay passion, excitement, or pain; a palliative. “There is one sweet lenitive at least for evils, which Nature holds out; so I took it kindly at her hands, and fell asleep.” — Sterne.