Entry 1 sense Webster, 1913 Lithagogue /(lĭth"ȧ*gŏg)/ · Lith·a·gogue · IPA 01 n. A medicine having, or supposed to have, the power of expelling calculous matter with the urine. 1. A medicine having, or supposed to have, the power of expelling calculous matter with the urine.(Med.)