D defs.my
Entry 2 senses Webster, 1913

Madonna

/məd-än'-ə/ · Ma·don·na · IPA /məˈdɒnə/
01 n. My lady; -- a term of address in Italian formerly used as the equivalent of Madame, but for which Signora is now substituted. Sometimes int…
  1. 1.
    My lady; -- a term of address in Italian formerly used as the equivalent of Madame, but for which Signora is now substituted. Sometimes introduced into English.
  2. 2.
    A picture of the Virgin Mary (usually with the babe).
    “The Italian painters are noted for drawing the Madonnas by their own wives or mistresses.” — Rymer.