Entry 1 sense Webster, 1913 Melissa /məl-ĭs'-ə/ · Me·lis·sa · IPA /məˈlɪsə/ 01 n. A genus of labiate herbs, including the balm, or bee balm (Melissa officinalis). 1. A genus of labiate herbs, including the balm, or bee balm (Melissa officinalis).(Bot.)