Entry 1 sense Webster, 1913 Miscegenation · Mis·ce·ge·na·tion · IPA /mɪˌsɛd͡ʒ.əˈneɪ.ʃən/ 01 n. A mixing of races; amalgamation, as by intermarriage of black and white. 1. A mixing of races; amalgamation, as by intermarriage of black and white.