Entry 1 sense Webster, 1913 Neuropathy /no͝or'-ōp-ăthˌ-ē/ · Neu·rop·a·thy · IPA /ˌnjuːˈrɒ.pə.θiː/ 01 n. An affection of the nervous system or of a nerve. 1. An affection of the nervous system or of a nerve.(Med.)