Entry 2 senses · 2 variants Webster, 1913 Ophidian · O·phid·i·an · IPA /oʊˈfɪdi.ən/ n. a. 01 n. One of the Ophidia; a snake or serpent. 1. One of the Ophidia; a snake or serpent.(Zool.) 02 a. Of or pertaining to the Ophidia; belonging to serpents. 1. Of or pertaining to the Ophidia; belonging to serpents.(Zool.)