Entry 1 sense Webster, 1913 Pigmentation /pĭgˌ-mən-tāsh'-ən/ · Pig·men·ta·tion · IPA /pˌɪɡməntˈeɪʃən/ 01 n. A deposition, esp. an excessive deposition, of coloring matter; as, pigmentation of the liver. 1. A deposition, esp. an excessive deposition, of coloring matter; as, pigmentation of the liver.(Physiol.)