Entry 1 sense Webster, 1913 Prescience /(prē"shĭ*ens [or] prē"shens; 277)/ · Pre·sci·ence · IPA /ˈpɹɛʃəns/ 01 n. Knowledge of events before they take place; foresight. 1. Knowledge of events before they take place; foresight. “God's certain prescience of the volitions of moral agents.” — J. Edwards.