Entry 1 sense Webster, 1913 Prima donna /prēm'-ə dän'-ə/ · Pri·ma don·na · IPA /ˌpɹiːməˈdɒnə/ 01 a. The first or chief female singer in an opera. pl. Prima donnas, Prime <pr>(#)</pr> Donne <pr>(#)</pr> ((#)) 1. The first or chief female singer in an opera.