Entry 1 sense Webster, 1913 Scleroderma /sklĭrˌ-əd-ẽrm'-ə/ · Scler·o·der·ma · IPA /sklˌɪrədˈɜrmə/ 01 n. A disease of adults, characterized by a diffuse rigidity and hardness of the skin. 1. A disease of adults, characterized by a diffuse rigidity and hardness of the skin.(Med.)