Entry 1 sense Webster, 1913 Spleenful · Spleen·ful · IPA /ˈspliːnfəl/ 01 a. Displaying, or affected with, spleen; angry; fretful; melancholy. 1. Displaying, or affected with, spleen; angry; fretful; melancholy. “Myself have calmed their spleenful mutiny.” — Shak. “Then rode Geraint, a little spleenful yet, Across the bridge that spann'd the dry ravine.” — Tennyson.