Entry 2 senses Webster, 1913 Stoicism /stō'-əs-ĭzˌ-əm/ · Sto·i·cism · IPA /ˈstoʊɪsɪzəm/ 01 n. The opinions and maxims of the Stoics. 1. The opinions and maxims of the Stoics. 2. A real or pretended indifference to pleasure or pain; insensibility; impassiveness.