Entry 1 sense Webster, 1913 Tequila /tək-ēl'-ə/ · Te·qui·la · IPA /ˌtəˈkiː.lə/ 01 n. An intoxicating liquor made from the maguey in the district of Tequila, Mexico. 1. An intoxicating liquor made from the maguey in the district of Tequila, Mexico.