Entry 4 senses · 2 variants Webster, 1913 Tweak /twēk/ · IPA /twiːk/ v. t. n. 01 v. t. To pinch and pull with a sudden jerk and twist; to twitch; as, to tweak the nose. 1. To pinch and pull with a sudden jerk and twist; to twitch; as, to tweak the nose. 02 n. A sharp pinch or jerk; a twist or twitch; as, a tweak of the nose. 1. A sharp pinch or jerk; a twist or twitch; as, a tweak of the nose. 2. Trouble; distress; tweag.[Obs.] 3. A prostitute.[Obs.]