Entry 2 senses · 2 variants Webster, 1913 Anodyne /(ăn"ō̇*dīn)/ · An·o·dyne · IPA /ˈæn.ə.daɪn/ a. n. 01 a. Serving to assuage pain; soothing. Also see Analgesic. 1. Serving to assuage pain; soothing. Also see Analgesic. See: Analgesic “The anodyne draught of oblivion.” — Burke. 02 n. Any medicine which allays pain, as an opiate or narcotic; anything that soothes disturbed feelings. 1. Any medicine which allays pain, as an opiate or narcotic; anything that soothes disturbed feelings.