Entry 2 senses · 2 variants Webster, 1913 Varioloid · Va·ri·o·loid · IPA a. n. 01 a. Resembling smallpox; pertaining to the disease called varioloid. 1. Resembling smallpox; pertaining to the disease called varioloid.(Med.) 02 n. The smallpox as modified by previous inoculation or vaccination. 1. The smallpox as modified by previous inoculation or vaccination.(Med.)